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The prophylactic antibiotic of choice has changed over the past few decades as resistance patterns have evolved. To better evaluate effectiveness the total number of patients experiencing significant improvement (20 degrees or greater) was calculated and compared. To our knowledge, detailed pharmacokinetic-pharmacodynamic studies of experimental fungal CNS infections are lacking. If there is concurrent ischemic heart disease without diabetes or CKD, and the patient is fit, also consider reducing the systolic pressure below 140 mm Hg.
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